2. Signaling Pathways
  3. GPCR/G Protein
  4. Prostaglandin Receptor

Prostaglandin Receptor

Prostaglandin Receptor

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Prostaglandin receptor, a sub-family of cell surface seven-transmembrane receptors, are the G-protein-coupled receptors. There are currently ten known prostaglandin receptors on various cell types. Prostaglandins bind to a subfamily of cell surface seven-transmembrane receptors, G-protein-coupled receptors. These receptors are named: DP1-2-DP1, DP2 receptors, EP1-4-EP1, EP2, EP3, EP4 receptors, FP-FP, IP1-2-IP1, IP2 receptors, TP-TP receptor. The prostaglandins are a group of hormone-like lipid compounds that are derived enzymatically from fatty acids and have important functions in the animalbody. There are currently ten known prostaglandin receptors on various cell types.

Prostaglandin Receptor Isoform Specific Products:

Prostaglandin Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-120973
    Butaprost free acid
    		Agonist
    Butaprost free acid is a selective prostaglandin E receptor (EP2) agonist with an EC50 of 33 nM and a Ki of 2.4 μM for murine EP2 receptor. Butaprost free acid is less activity against murine EP1, EP3 and EP4 receptors. Butaprost free acid attenuates fibrosis by hampering TGF-β/Smad2 signalling.
    Butaprost free acid
  • HY-121594
    GSK-269984B
    		Antagonist
    GSK-269984B is a potent EP1 antagonist. GSK-269984B has the potential for inflammatory pain research.
    GSK-269984B
  • HY-P1020A
    Nocistatin(human) TFA
    		Inhibitor
    Nocistatin (human) TFA blocks nociceptin-induced allodynia and hyperalgesia, and attenuates pain evoked by prostaglandin E2.
    Nocistatin(human) TFA
  • HY-113350
    Thromboxane A2
    		Activator
    Thromboxane A2 (TXA2) is a prostanoid mediator produced by the metabolism of Arachidonic acid (HY-109590) through the cyclooxygenase pathway. Thromboxane A2 activates the thromboxane-prostanoid (TP) receptors. Thromboxane A2 is a potent vasoconstrictor eicosanoid. Thromboxane A2 (TXA2) leads to potent vasoconstriction by stimulation of smooth muscle cells. Thromboxane A2 acts as s tonic immunoregulator to regulate adaptive immune responses.
    Thromboxane A2
  • HY-130594
    6α-Prostaglandin I1
    6α-Prostaglandin I1 (6α-PGI1) is an analogue of prostacycline I2 (PGI2) and is resistant to hydrolysis in aqueous solution.
    6α-Prostaglandin I1
  • HY-116843
    (15S)-15-Methylprostaglandin E2
    		Agonist
    (15S)-15-Methylprostaglandin E2 ((15R)-15-Methyl-PGE) is a prostaglandin E2 analog with the potential to prevent gastrointestinal bleeding and protect gastrointestinal cells.
    (15S)-15-Methylprostaglandin E2
  • HY-106961A
    (Z)-ONO 1301
    		Agonist
    (Z)-ONO 1301 is the isomer of ONO 1301 (HY-106961), and can be used as an experimental control. ONO 1301 (ONO-AP 500-02), a prostaglandin (PG) I2 mimetic, is an orally active, long-acting prostacyclin agonist with thromboxane-synthase inhibitory activity. ONO 1301 promotes production of hepatocyte growth factor (HGF) from various cell types and ameliorates ischemia-induced left ventricle dysfunction in the mouse, rat and pig.
    (Z)-ONO 1301
  • HY-B0131A
    Alprostadil sodium
    		Control
    Alprostadil sodium is a prostaglandin receptor ligand that exhibits Ki values of 36, 10, 1.1, 2.1, and 33 nM for the EP1, EP2, EP3, EP4, and IP receptors in mice, respectively. It promotes vasodilation and inhibits platelet aggregation, making it a useful vasodilator for investigating peripheral vascular disease.
    Alprostadil sodium
  • HY-163091
    EP4 receptor antagonist 5
    		Antagonist
    EP4 receptor antagonist 5 is a potent and selective prostanoid EP4 receptor antagonist that can reduce inflammation Freund’s adjuvant (CFA) model.
    EP4 receptor antagonist 5
  • HY-117953
    RU 59063
    		Inhibitor
    RU 59063 is an N-substituted arylthiohydantoin compound with antiandrogenic activity and high relative binding affinity for the rat androgen receptor. RU 59063 is a nonsteroidal androgen receptor that functions as a radioactive AR radioprobe (Ki: 0.71 nM, rAR) when its trifluoromethyl group is replaced by a similar hydrophobic iodine atom.
    RU 59063
  • HY-121314
    Cloprostenol
    Cloprostenol is a prostaglandin F2α (PGF2α (HY-12956)) analogue. Cloprostenol can induce luteolysis. Cloprostenol can be used for open-cervix pyometra research.
    Cloprostenol
  • HY-B0191S1
    Bimatoprost-d4
    		Agonist
    Bimatoprost-d4 is the deuterium labeled Bimatoprost. Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.
    Bimatoprost-d<sub>4</sub>
  • HY-125946
    Latanoprost lactone diol
    		99.86%
    Latanoprost lactone diol is an intermediate in the synthesis of Latanoprost. Latanoprost is a prostaglandin F2α analogue and an agonist for the FP prostanoid receptor, and lowers intraocular-pressure (IOP).
    Latanoprost lactone diol
  • HY-121091
    EP2 receptor agonist 4
    		Agonist
    EP2 receptor agonist 4 is a selective agonist for EP2 receptor with an EC50 of 43 nM.
    EP2 receptor agonist 4
  • HY-19755
    S-5751
    		Antagonist
    S-5751 is an orally active prostaglandin DP receptor antagonist. S-5751 inhibits cAMP generation in platelet-rich plasma induced by PGD2 with IC50 0.12 μM. S-5751 has anti-inflammatory activity. S-5751 can be used in asthma research.
    S-5751
  • HY-B0191A
    5,6-trans-Bimatoprost
    		Control
    5,6-trans-Bimatoprost is the isomer of Bimatoprost (HY-B0191), and can be used as an experimental control. Bimatoprost is a prostaglandin analogue that can be used in studies of ocular hypertension and glaucoma and also has anti-fat formation effects.
    5,6-trans-Bimatoprost
  • HY-116051
    16,16-Dimethylprostaglandin F2α
    16,16-Dimethylprostaglandin F2α (16,16-Dimethyl-PGF2α) is a potent analog of PGF2α (HY-12956), which exhibits similar binding potency as PGF2α does. 16,16-Dimethylprostaglandin F2α serves as a bronchoconstrictor.
    16,16-Dimethylprostaglandin F2α
  • HY-116250
    Prostaglandin D2-1-glyceryl ester
    		Agonist
    Prostaglandin D2-1-glyceryl ester (PGD2-G; PGD2 2-glyceryl ester).
    Prostaglandin D2-1-glyceryl ester
  • HY-108564
    L 655240
    		Antagonist
    L 655240 is thromboxane antagonist. L 655240 attenuates early ischemia- and reperfusion-induced arrhythmias in a canine model of coronary artery occlusion. L 655240 also involves in cancer and autoimmune disorders.
    L 655240
  • HY-19641
    AH13205
    		Agonist
    AH13205 is a selective prostanoid EP2-receptor agonist. AH13205 causes concentration-related relaxations of Carbachol (HY-B1208)-contracted trachea. AH13205 causes dose-related protection against Histamine (HY-B1204)-induced increases in respiratory rate.
    AH13205
Cat. No. Product Name / Synonyms Application Reactivity
Prostaglandin Receptor Isoform Comparison

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